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Research interests: The fusion of biology and nanotechnology, rooted in the principles and chemical pathways of living organisms, as well as the structure and function of natural macro- and nano-molecules present in living cells, stands out as one of the most promising strategies for addressing critical limitations in detection, diagnosis, and disease treatment commonly encountered in clinical trials. Our research interests are centered around the creation of multifunctional nanotools and nanotherapeutics utilizing noble metals, transition metal chalcogenides, carbon dots, and polyphenols for various biological and biomedical applications. These applications encompass real-time detection, cancer theranostics, and disease treatment.

Nobel metal or transition metal-based inorganic nanocomposites:

(1)        Ya-Ju Hsu, Amit Nain, Yu-Feng Lin, Yu-Ting Tseng, Yu-Jia Li, Arumugam Sangili, Pavitra Srivastava, Hui-Ling Yu, Yu-Fen Huang, Chih-Ching Huang*, and Huan-Tsung Chang*, “Self-Redox Reaction Driven In Situ Formation of Cu2O/Ti3C2Tx Nanosheets Boost the Photocatalytic Eradication of Multi-Drug Resistant Bacteria from Infected Wound.” J. Nanobiotechnology 2022, 20, 235. DOI: 10.1186/s12951-022-01428-3 (IF = 9.429, Q1, 14/158) SCI

(2)        Reesha Kakkadavath Vayalakkara, Chun-Liang Lo, Hsin-Hung Chen, Ming-Yin Shen, Ying-Chieh Yang, Arjun Sabu, Yu-Fen Huang*, and Hsin-Cheng Chiu*, “Photothermal/NO combination therapy from plasmonic hybrid nanotherapeutics against breast cancer.” J. Control. Release 2022, 345, 417-432. (IF = 9.776, Q1, 10/276) SCI, 本人為通訊作者

(3)        Amit Nain, Hao-Hsin Huang, Daniel M. Chevrier, Yu-Ting Tseng, Arumugam Sangili, Yu-Feng Lin, Yu-Fen Huang, Lung Chang*, Fu-Chieh Chang, Chih-Ching Huang, Fan-Gang Tseng*, and Huan-Tsung Chang*, “Catalytic and photoresponsive BiZ/CuxS heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections.” Nanoscale 2021, 13, 18632-18646. DOI: 10.1039/D1NR06358H (IF = 8.307, Q1, 37/179) SCI

(4)        Jingsong Lu, Zhenhu Guo, Wensheng Xie, Yongjie Chi, Junxin Zhang, Wanling Xu, Xiaoxiao Guo, Jielin Ye, Yen Wei, Hong Wu, Jing Yu, Yu-Fen Huang*, and Lingyun Zhao*, “Gold–iron selenide nanocomposites for amplified tumor oxidative stress-augmented photo-radiotherapy.” Biomater. Sci. 2021, 9, 3979-3988. (IF = 7.59, Q1, 9/44) SCI, 本人為通訊作者

(5)        Amit Nain, Shih-Chun Wei, Yu-Feng Lin, Yu-Ting Tseng, Ranju Prasad Mandal, Yu-Fen Huang, Chih-Ching Huang*, Fan-Gang Tseng*, and Huan-Tsung Chang*, “Copper Sulfide Nanoassemblies for Catalytic and Photoresponsive Eradication of Bacteria from Infected Wounds.” ACS Appl. Mater. Interfaces 2021, 13, 7865-7878. (IF = 10.383, Q1, 49/345) SCI

(6)        Andrea C. del Valle, Chih-Kuang Yeh, and Yu-Fen Huang*, “Near Infrared-Activatable Platinum-Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance.” Adv. Healthc. Mater. 2020, 200864. DOI: 10.1002/adhm.202000864 (IF = 11.092, Q1, 8/98) SCI, 本人為通訊作者

(7)        Chun-Chiao Chuang, Yi-Ning Chen, Yi-Ya Wang, Yu-Chen Huang, Ssu-Yu Lin, Rih-Yang Huang, Yu-Yun Jang, Yu-Fen Huang, and Chien-Wen Chang*, "Stem Cell-Based Delivery of Gold/Chlorin e6 Nanocomplexes for Combined Photothermal and Photodynamic Therapy." ACS Appl. Mater. Interfaces 2020, 12, 30021-30030. (IF = 10.383, Q1, 49/345) SCI

(8)        Andrea C. del Valle, Cheng-Kuan Su, Yuh-Chang Sun, and Yu-Fen Huang*, “NIR-Cleavable Drug Adducts of Gold Nanostars for Overcoming Multidrug-Resistant Tumors.” Biomater. Sci. 2020, 8, 1934-1950. DOI: 10.1039/C9BM01813A (IF = 7.59, Q1, 9/44) SCI, 本人為通訊作者

(9)        You-Hong You, Yu-Feng Lin, Bhanu Nirosha, Huan-Tsung Chang, and Yu-Fen Huang*, “Polydopamine-coated gold nanostar for combined antitumor and antiangiogenic therapy in multidrug-resistant breast cancer.” Nanotheranostics 2019, 3, 266-283. Doi:10.7150/ntno.36842本人為通訊作者

(10)        Yu-Cheng Chang, Andrea C. Del Valle, Huan-Pu Yeh, Yue He*, and Yu-Fen Huang*, “Development of photo-activated ROS-responsive nanoplatform as a dual-functional drug carrier in combinational chemo-photodynamic therapy.” Front. Chem. 2019, 6, 647. (IF = 5.545, Q2, 59/179) SCI, 本人為通訊作者

(11)        Huan-Pu Yeh, Andrea C. del Valle, Ming-Chen Syu, Yu Qian, Yu-Cheng Chang, and Yu-Fen, Huang*, “A New Photosensitized Oxidation-Responsive Nanoplatform for Controlled Drug Release and Photodynamic Cancer Therapy.” ACS Appl. Mater. Interfaces 2018, 10, 21160-21172. (IF = 10.383, Q1, 49/345) SCI, 本人為通訊作者

(12)        Hsien-Ting Chiu, Chung-Hao Chen, Meng-Lin Li, Cheng-Kuan Su, Yuh-Chang Sun, Chi-Shiun Chiang, and Yu-Fen Huang*, “Bioprosthesis of Core-Shell Gold Nanorod-Serum Albumin Nanoimitation: A Half-Native and Half-Artificial Nanohybrid for Cancer Theranostics.” Chem. Mater. 2018, 30, 729-747. (IF = 10.508, Q1, 48/345) SCI, 本人為通訊作者

(13)        Hsien-Ting Chiu, Cheng-Kuan Su, Yuh-Chang Sun, Chi-Shiun Chiang, and Yu-Fen Huang*, “Albumin-Gold Nanorod Nanoplatform for Cell-Mediated Tumoritropic Delivery with Homogenous ChemoDrug Distribution and Enhanced Retention Ability.” Theranostics 2017, 7, 3034-3052. (IF = 11.6, Q1, 13/139) SCI, 本人為通訊作者

(14)        Yue He, Andrea del Valle, Yu Qian, and Yu-Fen Huang*, “Near infrared light-mediated enhancement of reactive oxygen species generation through electron transfer from graphene oxide to iron hydroxide/oxide.” Nanoscale 2017, 9, 1559-1566. DOI: 10.1039/C6NR08784A  (IF = 8.307, Q1, 37/179) SCI, 本人為通訊作者

Natural compounds or carbon-based nanocomposites:

(1)        Yu-Jia Li, Shih-Chun Wei, Han-Wei Chu, Hong-Jyuan Jian, Anisha Anand, Amit Nain, Yu-Fen Huang*, Huan-Tsung Chang, Chih-Ching Huang, and Jui-Yang Lai*, “Poly-quercetin-based nanoVelcro as a multifunctional wound dressing for effective treatment of chronic wound infections.” Chem. Eng. J. 2022, 437, 135315. DOI: 10.1016/j.cej.2022.135315 (IF = 16.744, Q1, 4/142) SCI, 本人為通訊作者

(2)        Ren-Siang Wu, Yu-Syuan Lin, Amit Nain, Binesh Unnikrishnan, Yu-Feng Lin, Cheng-Ruei Yang, Tzu-Heng Chen, Yu-Fen Huang*, Chih-Ching Huang, and Huan-Tsung Chang*, "Evaluation of Chemotherapeutic Response in Living Cells Using Subcellular Organelle‒Selective Amphipathic Carbon Dots." Biosens. Bioelectron. 2022, 211, 114362. (IF = 12.545, Q1, 10/158) SCI, 本人為通訊作者

(3)        Shun-Ruei Hu, Chang-Ruei Yang, Yu-Fen Huang, Chih-Ching Huang, Yen-Ling Chen*, and Huan-Tsung Chang*, “Ratiometric Fluorescence Probe of Vesicle-like Carbon Dots and Gold Clusters for Quantitation of Cholesterol.” Chemosensors 2022, 10 (5), 160. DOI: 10.3390/chemosensors10050160 (IF = 4.229, Q2, 25/87) SCI

(4)        Pei-Hsuan Lin, Hong-Jyuan Jian, Yu-Jia Li, Yu-Fen Huang*, Anisha Anand, Chih-Ching Huang, Han-Jia Lin, and Jui-Yang Lai*, “Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels.” Acta Biomater. 2022, 141, 140-150. DOI: 10.1016/j.actbio.2022.01.044 (IF = 10.633, Q1, 13/98) SCI, 本人為通訊作者

(5)        Yu-Syuan Lin, Li-Wei Chuang, Yu-Feng Lin, Shun-Rue Hu, Chih-Ching Huang, Yu-Fen Huang*, and Huan-Tsung Chang*, “Development of Fluorescent Carbon Nanoparticle-Based Probes for Intracellular pH and Hypochlorite Sensing.” Chemosensors 2022, 10 (2). DOI: 10.3390/chemosensors10020064 (IF = 4.229, Q2, 25/87) SCI, 本人為通訊作者

(6)        Hong-Jyuan Jian, Jiantao Yu, Yu-Jia Li, Binesh Unnikrishnan, Yu-Fen Huang, Li-Jyuan Luo, David Hui-Kang Ma, Scott G. Harroun, Huan-Tsung Chang, Han-Jia Lin, Jui-Yang Lai*, and Chih-Ching Huang*, “Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation.” Chem Eng. J. 2020, 386, 123913. (IF = 16.744, Q1, 4/142) SCI

(7)        Yu-Jia Li, Li-Jyuan Luo, Scott G. Harroun, Shih-Chun Wei, Binesh Unnikrishnan, Huan-Tsung Chang, Yu-Fen Huang, Jui-Yang Lai*, and Chih-Ching Huang*, “Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease.” Nanoscale 2019, 11, 5580-5594. (IF = 8.307, Q1, 37/179) SCI

Review articles:

(1)        Yu-Feng Lin, Cheng-Ruei Yang, Yu-Fen Huang*, and Huan-Tsung Chang*, “Fluorescent carbon dots and noble metal nanoclusters for sensing applications: Minireview.” J. Chin. Chem. Soc. 2022, in press. (IF = 1.753, Q4, 135/179) SCI, 本人為通訊作者

(2)        Arjun Sabu, Te-I Liu, Siew Suan Ng, Ruey-An Doong, Yu-Fen Huang*, and Hsin-Cheng Chiu*, “Nanomedicines Targeting Glioma Stem Cells.” ACS Appl. Mater. Interfaces 2022, in press. (IF = 10.383, Q1, 49/345) SCI, 本人為通訊作者

(3)        Arjun Sabu, Jui-Yen Lin, Ruey-An Doong, Yu-Fen Huang*, and Hsin-Cheng Chiu*, “Prospects of an engineered tumor-targeted nanotheranostic platform based on NIR-responsive upconversion nanoparticles.” Mater. Adv. 2021, 2, 7101-7117. DOI: 10.1039/D1MA00563D. 本人為通訊作者

(4)        Yu-Syuan Lin, Yu-Feng Lin, Amit Nain, Yu-Fen Huang*, and Huan-Tsung Chang*, “A critical review of copper nanoclusters for monitoring of water quality.” Sens. Actuators Rep. 2021, 3, 100026. 本人為通訊作者

(5)        Yue He*, Cong-Ying Wen, Zhi-Jun Guo, and Yu-Fen Huang*, “Noble metal nanomaterial-based aptasensors for microbial toxin detection.” J. Food. Drug Anal. 2020, 28, Iss. 4, Article 3. DOI: 10.38212/2224-6614.1155. (IF = 6.157, Q1, 27/143) SCI, 本人為通訊作者




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